KY 94 East in Graves County is blocked near the Lynnville community due to an overturned truck loaded with live chickens.
Kentucky Transportation Cabinet spokesperson Keith Todd says some of the chickens have reportedly escaped from the truck and are being rounded up.
The accident is along KY 93 between the 11 and 14 mile marker.
Todd says the estimated duration is three hours.
Local fire departments have established a detour via KY 381, KY 83, and KY 303.